Plasmin Activation in Clotting Blood

ERS P. Barkhan, M.D., London, England T. H. Bothwell, M.D., Johannesburg, South Africa T. E. Brittingham, M.D., Nashville, Tenn. Jacque Caen, M.D., Paris, France J. B. Chatterjea, M.D., Calcutta, india Pietro deNicola, M.D., Pavia, italy Ludvik Donner, M.D., Prague, Czechoslovakia A. J. Erslev, M.D., Philadelphia H. Hugh Fudenberg, M.D., San Francisco Katsuhiro Fukutake, M.D., Tokyo, Japan Robert Goldstein, NI.D., New York City Ira Green, M.D., New York City F. W. Gunz, M.D., Christchurch, New Zealand Susanna R. Hollan, M.D., Budapest, Hungary Harry S. Jacob, M.D., Boston, Mass. Michel Jamra, M.D., Sao Paulo, Brazil Oliver P. Jones, M.D., Buffalo Joseph Kassirsky, M.D., Moscow, U.S.S.R. Sven-Age Killmann, M.D., Copenhagen, Denmark Frederick A. Klipstein, M.D., New York City E. Kowalski, M.D., Warsaw, Poland E. A. Loeliger, M.D., Leiden, The Netherlands Cohn Macpherson, M.D., Columbus, Ohio Georges Math#{233}, M.D., Paris, France Bracha Ramot, M.D., Tel Aviv, Israel Helen NI. Ranney, M.D., New York City Peter G. Reizenstein, M.D., Stockholm, Sweden Edgardo S. Sack, M.D., Buenos Aires, Argentina Julian B. Schorr, M.D., New York City Ralph 0. Wallerstein, M.D., San Francisco INDUCTION OF TOLERANCE TO BovINE SERUM ALBUMIN BY MEANS OF WHOLE-BODY X-RAm.4TION. W. D. Lirucott and W. 0. Weigle. From Scripps Clinic. La Jolla. Calif. J. Immun. 94: 430-436, 1965. Adult New Zealand rabbits given 500 or 550 r of x-radiation, followed 2 and 7 days later by intravenous injections totaLng 300 mug. of bovine serum albumin (BSA), were made tolerant to BSA hut not to HCG. They were unable to make antibodies against BSA antigen when appropriately challenged 2 months later. The amount of BSA per Kg. required to induce tolerance appeared to be approximately the same for irradiated adult rabbits and for neonates-H. H. F. RADIOSENSITIVITY OF THE IMMUNE RESPONSE TO SHEEP Rm CELLS IN THE MOUSE, AS MEASURED BY THE HEMOLYTIC PLAQUE METHOD. J. C. Kennedy, I. E. Till, L. Siminovitch and E. A. McCulloch. From the University of Toronto, Toronto, Canada. J. Inimun. 94:715-722. 1965. The capacity of adult mnale mice to respond to injection of sheep erythrocytes by production of hemolytic plaque-forming cells was decreased by irradiation (Co6#{176} y-rays). The spleens of normal mice contained a minimumu of 10 cells which did not produce hemolysin. but which responded to injection of antigen by proliferation and differentiation into hemolysin-producing cells. When these cells, which may be termed antigensensitive cells, were rendered incapable of proliferation by radiation, they were not replaced to a significant degree for at least 10 days-H. II. F. DIFFERENCES IN THE ELECTROPHORETIC MOBILITY OF ANTIBODY FROM INBRED STRAINS OF MICE. I. L. Fahey, W. Barth and Z. Ovary. From New York University School of Medicine, New York. J. Immun. 94:819-822, 1965. Genetic factors evidently infiumence the electrophoretic mobility of antibody in mice. Some of the factors determining these differences in the electrophoretic mobility of immunoglobuhin molecules are independent of antigen-binding (antibody) sites and the skin-sensitizing site-H. H. F.